British Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation against an underground arms cache in Syria operated by the IS group, according to the UK Ministry of Defence.
The facility, located using reconnaissance, was assessed as containing munitions and bombs, the release indicated, and was positioned in hills just north of Palmyra in central Syria.
"Our aircraft used laser-guided Paveway IV weapons to strike a series of approach shafts providing entry to the site... early reports are that the strike was effective," the ministry announced.
There was no indication of any civilian casualties in the operation late on Saturday and every plane involved made a safe return, the MoD added.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as the so-called Islamic State - established militant control over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This action demonstrates our UK leadership, and determination to work closely with allied nations, to eliminate any resurgence of IS and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the minister stated.
RAF aircraft have performed patrols over Syrian airspace to "forestall any attempted comeback" of Islamic State subsequent to its military defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I extend gratitude to the personnel of British forces who took part in this operation for their skill and their valour," the Defence Secretary added. "They were part of thousands of British troops stationed over Christmas and New Year. This action, to eliminate militants who endanger our way of life, demonstrates how British military are ready to step up, continuously, ensuring Britain's security within its borders and powerful internationally."
In December, the United States armed forces conducted what it called a "major assault" targeting IS targets in Syria, after an ambush killed two US troops and a local interpreter in the Palmyra area.
The United Nations reports Daesh still has between 5,000 and 7,000 fighters in both countries.